A skin rejuvenation mesogun injector is a mesotherapy device that delivers hyaluronic acid and nutrient solutions directly into the dermis, placing actives about 1.28mm below the surface at an adjustable 0-2.5mm depth. The Pmise-M01 uses vacuum negative pressure and multi-needle injection for precise, non-surgical skin hydration and rejuvenation with no downtime.
Pmise-M01
A skin rejuvenation mesogun injector — also called a mesotherapy gun or skin booster injector — is a professional device that automates the injection of hyaluronic acid and nutrient solutions into the dermis. Instead of relying on freehand needle work, the machine lifts the skin with vacuum negative pressure and places actives at a controlled 0-2.5mm depth with dosing precision down to 0.0080cc. It is built for medical aesthetic clinics, beauty salons and spas that offer skin hydration, skin booster and anti-aging programs, and for distributors who supply professional skin rejuvenation equipment. Because the treatment is non-surgical and has no downtime, it fits high-frequency treatment menus, and the Pmise-M01 covered on this page is supplied factory-direct.
The skin rejuvenation mesogun injector applies acoustic pressure technology, placing nutrients accurately about 1.28mm under the dermis. It lifts the skin slightly with vacuum negative pressure before applying acoustic pressure, then injects nutrient solution and hyaluronic acid once the skin is tightened. The depth, dose, speed and absorption can all be controlled. The micro-needle releases the pressure before withdrawal, so it does not cause any loss of nutrients. Long-term use can help maintain the dynamic equilibrium of collagen, effectively address multiple facial skin problems and achieve relatively lasting improvement of the skin.
For surface-level deep cleansing and hydration, compare it with our water & oxygen jet facial machine; for non-surgical face lifting and tightening, see the HIFU machine.
Buyers researching a mesotherapy gun usually weigh it against freehand injection and surface hydration treatments. The table below summarizes how the three approaches differ.
| Technology | Best for | Depth / wavelength | Downtime | Suitable buyer |
| Mesogun injector (Pmise-M01) | Dermal hydration, photoaged skin, atrophic scars, enlarged pores, neck wrinkles | 0-2.5mm adjustable dermal injection | None | Clinics, medspas and salons selling skin booster courses |
| Manual mesotherapy | The same dermal indications when performed by an experienced injector | Depth varies with operator technique | — | Practitioners with strong injection skills and low treatment volume |
| Hydra facial (water & oxygen jet facial machine) | Surface deep cleansing and surface hydration | Skin surface only, non-invasive spray | None | Salons and spas focused on facial cleansing menus |
| Pmise-M01 | |
| LCD Screen Type | 8'16 Color Touch LCD Display |
| Injection Depth | 0-2.5mm(Adjustable) |
| Syringe Type | 1cc 1.5cc 2.5cc 3cc 5cc |
| Injection Speed | VF F N S VS |
| Injection Mode | Intermittent, Single |
| Injection Needle | 5Pin 31G, 9Pin 32G |
| Storage Temperature | -10~60°C |
| Storage Humidity | 10~90%RH |
| Size | 300*230*145mm |
| Weight | 4.0Kg |
| Power Supply | AC220V±10% or AC110V±10%, 50Hz~60Hz |
| Safety Controller | Automatic Self-Checking and Alarm System |
Get factory price and full technical specifications for Pmise-M01 ›
Pmise supports every M01 mesotherapy gun with a one-year warranty from the date of receipt and lifetime maintenance after the warranty period. Technical consulting is answered within 30 minutes, and quotations are issued within 12-24 hours. Behind the machine stands an expert team of more than 50 specialists and over 100 technicians, with door-to-door service arranged at least twice a year. Pmise equipment has been exported to America, Europe, the Middle East, Africa and Southeast Asia, so voltage configuration and shipping for your market are routine work rather than special requests.
A mesogun injector is used for mesotherapy-style skin rejuvenation: it injects hyaluronic acid and nutrient solutions into the dermis to hydrate skin, improve photoaged areas on the forehead, temples and cheeks, refine enlarged pores, soften neck wrinkles and improve atrophic scars. It is also used for cheek and lip augmentation treatments.
Mesogun treatment is a non-surgical injection procedure performed with very fine micro-needles (5-pin 31G or 9-pin 32G). The Pmise-M01 lifts the skin with vacuum negative pressure before injecting, which helps keep the procedure comfortable, and there is no downtime after injection, so patients can return to daily activities immediately.
The Pmise-M01 mesogun injects at an adjustable depth of 0-2.5mm, and nutrients are typically placed about 1.28mm under the skin into the dermis. Because the micro-needle releases pressure before withdrawal, the dermis absorbs more than 98 percent of the nutrients, around 70 percent more than traditional manual methods.
A mesogun injects hyaluronic acid and nutrients directly into the dermis with micro-needles, while a water and oxygen jet facial machine sprays pressurized water and oxygen onto the skin surface for cleansing and surface hydration. The mesogun works deeper in the skin, so it targets wrinkles, scars and lasting rejuvenation rather than surface cleaning.
Choose a mesogun injector when you need consistent, repeatable results across operators: the Pmise-M01 controls depth from 0-2.5mm, doses as precisely as 0.0080cc and achieves over 98 percent dermal absorption. Manual mesotherapy needs no equipment investment, but depth, dose and outcome depend entirely on the individual practitioner's technique.
Every Pmise-M01 ships with a one-year warranty starting from the date you receive the machine, plus lifetime maintenance afterwards. Our service team answers technical consulting within 30 minutes, and a support network of more than 100 technicians backs installation and daily use. Quotations are issued within 12-24 hours.
The price of a professional mesogun injector machine depends on configuration, needle cartridges and order quantity. Pmise supplies the M01 mesogun directly from the factory, so clinics and distributors get competitive wholesale pricing. Contact us through the form below for a detailed quotation, current price list and shipping terms.
Treatment results vary by skin type, indication and operator settings. Professional operator training is required before clinical use.
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